We assessed the three main outcomes with the GRADE approach, and found low-certainty evidence that antibiotic treatment may prevent pyelonephritis, preterm birth, and birthweight less than 2500 g.Īntibiotic treatment may reduce the risk of kidney infections in pregnant women who have a urine infection but show no symptoms of infection. None of the studies adequately assessed any adverse effects of antibiotic treatment for the mother or her baby, and often the way the study was done was not well described. They may also reduce the incidence of preterm births (three studies, 327 women) and low birthweight babies (six studies, 1437 babies). Antibiotics may be effective in reducing the incidence of kidney infection in the mother (12 studies, 2017 women) and clearing the infection from the urine (four studies, 596 women). We found 15 randomised controlled studies involving over 2000 pregnant women with urinary infections, but no symptoms. The infection may also contribute to a baby who is born preterm (before 37 weeks), or at a low birthweight (weighs less than 2500 g (5.5 pounds)). Because of the changes happening in their body, pregnant women are more likely to develop a kidney infection (pyelonephritis) if they have a urinary infection. Can giving antibiotics to pregnant women who have a urinary infection but no symptoms improve the outcomes for women and their babies?Ī bacterial infection of the urine without any of the typical symptoms that are associated with a urinary infection (asymptomatic bacteriuria) occurs in a number (2% to 15%) of pregnancies.
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